Creatine
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| I'm a medical student and I also use creatine. I would like to
explain the function of creatine. Creatine is produced naturally
in the liver Glycine+Arginine->ornithine and guanidinoacetate
which is then methylated by S-adenosylmethionine to form creatine.
Creatine travels from the liver to other tissues where it is converted
to creatine phosphate. ATP phosphorylates creatine to form creatine
phosphate. Muscle and brain contain large amounts of creatine phosphate.
It provides a small reservoir of high-energy phosphate which can
regenerate ATP from ADP. It plays a particularly important role
in muscle during the early stages of exercise. After all the creatine
is depleted muscle metabolism depends largely in glycogen. This
is the reason loading muscles with creatine makes us feel stronger
during the first sets.
Creatine later turns into creatinine and is excreted by the kidneys.
The amount is proportional to body mass. So , doctors use creatinine
as a measure for body mass and renal function. As far as I know,
creatine has no effect on stretch receptors in muscles. Stretch
receptors are sensors that produce "pain" when the muscles
limit it's reached. Many of these supplements are not regulated
and few people know how they work and what the long-term effects
are. One recommendation is that before you use any supplement,
consult a physician or don't only work on your muscles, work on
your brain and hit the books! Sorry for the lecture. I hope this
information is of usefulness.
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| Thank you for your lecture. I'm serious! I'm trying to talk my
dad out of taking Creatine and this will give credence to my arguments
against it. I am arguing against it because I don't think it works.
We discussed it in one of my pre-requisite courses for the school
of Kineisiology at S.F.U. Everything I heard gives me no desire
to take it. Thanks again for your enlightening piece.
Sevran
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